Preparation of potential cell-permeant nucleoside-2',3'-cyclic phosphate precursors.
نویسندگان
چکیده
Uridine-3'-phosphorothiolate triesters bearing lipophilic moieties were prepared via Michaelis-Arbuzov chemistry. Subsequent deprotection of the S-cholesteryl phosphorothiolate triester afforded the corresponding diester which underwent spontaneous Cyclization to cleanly afford uridine 2',3'-cyclic phosphate. This transesterification reaction could be expedited by treatment with iodine under mild, neutral conditions.
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ورودعنوان ژورنال:
- Nucleosides, nucleotides & nucleic acids
دوره 26 3 شماره
صفحات -
تاریخ انتشار 2007